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2019

2019

J Clin Invest. doi: 10.1172/JCI123835

Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity

Retinopathy of prematurity (ROP) is a complication of treating preterm infants with O2. It is estimated that as many as 10% of very premature infants...

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Nat Commun. 2019 Jul 5;10(1):2987. doi: 10.1038/s41467-019-10839-0

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Idiopathic pulmonary fibrosis is a fatal, incurable lung disease in which the intricate alveolar network of the human lung is progressively replaced...

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J Clin Invest. 129(7):2775-2791. doi: 10.1172/JCI123825. eCollection 2019 Jun 17.

Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

New signaling pathway of blood pressure regulation

Tension and diameter of blood vessels are continuously modulated by vasodilator and...

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N Engl J Med,  2019 Jun 20;380(25):2418-2428. doi: 10.1056/NEJMoa1716734.

Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease

Guiding patients with stable chest pain non-invasively with perfusion cardiovascular magnetic resonance is non-inferior to invasive angiography and...

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EMBO J. 2019 Jun 17;38(12). pii: e102099. doi: 10.15252/embj.2019102099. Epub 2019 Apr 26

Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo

The lung is a complex and highly specialized organ that carries out the vital task of gas exchange to deliver oxygen and concomitantly remove carbon...

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Nat Commun. 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Hypoxia, defined as a reduction in the amount of oxygen available to a cell, tissue, or organism, is a fundamental and life-threatening biological...

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Nat Commun. 2019 May 17;10(1):2204. doi: 10.1038/s41467-019-10135-x.

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a devastating disease with poor prognosis and limited therapeutic options. Current vasodilator treatment appr...

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Science. 2019 364(6436):188-193

Deubiquitinase USP10 regulates Notch signaling in the endothelium

Signaling by Notch receptors is an essential cell-cell communication mechanism essential for developmental patterning throughout evolution,...

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Circulation. 2019 Mar 5;139(10):1320-1334. doi: 10.1161/CIRCULATIONAHA.117.029015

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation.

The majority of the human genome comprises noncoding sequences, which are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit...

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EMBO Mol Med. 2019 Feb 15. pii: e9448. doi: 10.15252/emmm.201809448

Targeting miR-34a/Pdgfra interactions partially corrects alveologenesis in experimental bronchopulmonary dysplasia

Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth characterized by arrested lung alveolarization, which generates lungs that...

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JAMA Cardiol. 2019 Jan 1;4(1):25-33. doi: 10.1001/jamacardio.2018.3965

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

Somatic mutations causing the clonal expansion of hematopoietic cells, known as clonal hematopoiesis of indeterminate potential (CHIP), are increased...

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