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2018

2018

Nat Genet. 2018 Jun 4. doi: 10.1038/s41588-018-0139-3. [Epub ahead of print]

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which are important regulators of different nuclear processes by...

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Ann Intern Med. [Epub ahead of print 22 May 2018] doi: 10.7326/M17-1540

Amyloid-β (1-40) and Mortality in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome: A Cohort Study

 Amyloid-β (1-40) (Aβ40) is implicated in mechanisms related to plaque destabilization and correlates with adverse outcomes in stable coronary artery...

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Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster

Muscle stem cells undergo a dramatic metabolic switch to oxidative phosphorylation during differentiation, which is achieved by massively increased...

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Circ Res. 2018 Mar 2;122(5):670-677. doi: 10.1161/CIRCRESAHA.117.312310. Epub 2018 Jan 22

Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization

The circulatory system is essential to maintain organ function by providing oxygen and nutrients. In adults, the turnover of vasculature in most...

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Cancer Res. 2018 Jan 16. pii: canres.1346.2017. doi: 10.1158/0008-5472.CAN-17-1346. [Epub ahead of print]

PHD3 controls lung cancer metastasis and resistance to EGFR inhibitors through TGFα

Lung cancer is the leading cause of cancer-related death worldwide, in large part due to its high propensity to metastasize and develop therapy...

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Nat Commun. 2018 Jan 16;9(1):237. doi: 10.1038/s41467-017-02431-1.

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2.

High-throughput sequencing-based profiling of 15 different cell lines revealed that ~74% of the human genome is transcribed, however, only ~2%...

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