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2018

2018

Nat Commun. 2018 Nov 19;9(1):4877

Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement

Heart is the first organ that emerges during mammalian embryonic development. The long-lasting challenges for understanding heart development are to...

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Nat Commun. 2018;9:4077

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs) oxidize only a minor fraction of glucose in...

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J. Exp. Med. (2018)

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

The vascular endothelium is constantly exposed to mechanical forces including fluid shear stress exerted by the flowing blood. Endothelial cells can...

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Science. 2018 Aug 24;361(6404). pii: eaao2861. doi: 10.1126/science.aao2861

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system

The brain is composed by an intricate network of neurons, glial cells and vessels that closely interact to develop a functional organ and to maintain...

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Circulation. 2018; In Press- doi: 10.1161/CIRCULATIONAHA.118.034757

Cystathionine γ ­lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherogenesis

Despite intensive therapy, the clinical manifestations of atherosclerosis remain the primary cause of morbidity and mortality worldwide....

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Nat Genet. 2018 Jun 4. doi: 10.1038/s41588-018-0139-3. [Epub ahead of print]

MiCEE is a ncRNA-protein complex that mediates epigenetic silencing and nucleolar organization

The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which are important regulators of different nuclear processes by...

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Ann Intern Med. [Epub ahead of print 22 May 2018] doi: 10.7326/M17-1540

Amyloid-β (1-40) and Mortality in Patients With Non–ST-Segment Elevation Acute Coronary Syndrome: A Cohort Study

 Amyloid-β (1-40) (Aβ40) is implicated in mechanisms related to plaque destabilization and correlates with adverse outcomes in stable coronary artery...

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Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster

Muscle stem cells undergo a dramatic metabolic switch to oxidative phosphorylation during differentiation, which is achieved by massively increased...

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Circ Res. 2018 Mar 2;122(5):670-677. doi: 10.1161/CIRCRESAHA.117.312310. Epub 2018 Jan 22

Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization

The circulatory system is essential to maintain organ function by providing oxygen and nutrients. In adults, the turnover of vasculature in most...

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Cancer Res. 2018 Jan 16. pii: canres.1346.2017. doi: 10.1158/0008-5472.CAN-17-1346. [Epub ahead of print]

PHD3 controls lung cancer metastasis and resistance to EGFR inhibitors through TGFα

Lung cancer is the leading cause of cancer-related death worldwide, in large part due to its high propensity to metastasize and develop therapy...

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Nat Commun. 2018 Jan 16;9(1):237. doi: 10.1038/s41467-017-02431-1.

The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2.

High-throughput sequencing-based profiling of 15 different cell lines revealed that ~74% of the human genome is transcribed, however, only ~2%...

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