The Problem: Cardio-Pulmonary diseases are changing
The therapy of cardio-pulmonary diseases has seen much progress in recent years. For example, whereas the early phase of a severe heart failure was usually not survived in the past, the current treatments has much improved the early outcome. This progress, however, came with a price: The rate of chronic congestive heart failure has increased. As this disease is in large parts a consequence of a mal-adaptive remodeling process, novel therapies are needed to prevent this deleterious adaptive process.