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2017

2017

Nature. 2017 Dec 14;552(7684):248-252. doi: 10.1038/nature25013. Epub 2017 Dec 6.

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy.

Diabetic retinopathy is an important cause of blindness in adults, and is characterized by progressive loss of vascular cells and slow dissolution of...

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Nat Commun. 2017 Nov 15;8(1):1525. doi: 10.1038/s41467-017-01555-8.

Transient cardiomyocyte fusion regulates cardiac development in zebrafish.

Cell fusion is an indispensable process in diverse physiological and pathological events. For example fusion of myoblasts into multinucleated syncytia...

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Cell Rep. 2017 Oct 3;21(1):84-96. doi: 10.1016/j.celrep.2017.09.019.

GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse.

Neuronal activity at the synapse induces changes in synaptic strength by altering the abundance of receptors at the membrane. Thus, changes in AMPA...

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Nat Commun. 2017 Jun 16;8:15700. doi: 10.1038/ncomms15700.

Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system.

G-protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in eukaryotes; they transduce signals of numerous...

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Am J Respir Cell Mol Biol. 2017 Jul 5. doi: 10.1165/rcmb.2016-0358OC. [Epub ahead of print]

Restoration of Megalin-mediated Clearance of Alveolar Protein as a Novel Therapeutic Approach for Acute Lung Injury.

Acute respiratory distress syndrome (ARDS) constitutes a significant disease burden with regard to both morbidity and mortality. Current therapies are...

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J Exp Med. 2017 Jul 24. pii: jem.20160392. doi: 10.1084/jem.20160392. [Epub ahead of print]

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis viaNLRP3/IL-1β.

Tumor-associated inflammation contributes to all stages of tumor development. Among the tumor-infiltrating immune cells that propagate cancer,...

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Circ Res. 2017 Jun 15. pii: CIRCRESAHA.116.310482. doi: 10.1161/CIRCRESAHA.116.310482.

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing.

Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion...

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Nat Commun. 2017 May 2;8:15162. doi: 10.1038/ncomms15162.

Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice.

MicroRNAs (miRs) are small non-coding RNAs that posttranscriptionally regulate gene expression. They imply great therapeutic potential by application...

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J Clin Invest. 2017 Apr 24. pii: 88725. doi: 10.1172/JCI88725. [Epub ahead of print]

Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.

Congenital heart disease (CHD) represents the most prevalent inborn anomaly. Only a minority of CHD cases is attributed to genetic causes, suggesting...

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Circulation. 2017 Mar 28. pii: CIRCULATIONAHA.116.026991. doi: 10.1161/CIRCULATIONAHA.116.026991.

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function.

The endothelium forms the vascular barrier to maintain vessel function. Healthy endothelium prevents thrombus formation and inflammatory cell...

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Cell Stem Cell. 2017 Feb 2; 20(2):261-273.e3

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a rare, yet life-threatening disease with very poor prognosis, leading to death mostly due to respiratory...

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EMBO Mol Med. 2016 Dec 1; 8(12):1380-1389.

Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Early LC diagnosis is crucial to reduce the high case fatality rate of this...

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